Cell-targeted platinum nanoparticles and nanoparticle clusters.

نویسندگان

  • Stefanie Papst
  • Margaret A Brimble
  • Clive W Evans
  • Daniel J Verdon
  • Vaughan Feisst
  • P Rod Dunbar
  • Richard D Tilley
  • David E Williams
چکیده

Herein, we report the facile preparation of cell-targeted platinum nanoparticles (PtNPs), through the design of peptides that, as a single molecule added in small concentration during the synthesis, control the size of PtNP clusters during their growth, stabilise the PtNPs in aqueous suspension and enable the functionalisation of the PtNPs with a versatile range of cell-targeting ligands. Water-soluble PtNPs targeted respectively at blood group antigens and at integrin receptors are demonstrated.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 13 23  شماره 

صفحات  -

تاریخ انتشار 2015